The worsening effect of paroxysmal atrial fibrillation on left ventricular function and deformation in type 2 diabetes mellitus patients: a 3.0 T cardiovascular magnetic resonance feature tracking study
Authors' conclusion
In patients with T2DM, the presence of paroxysmal AF further exacerbates LV function and deformation. Proactive prevention, regular detection and early intervention of AF could potentially benefit T2DM patients.
Study context
- Population
- T2DM patients with or without paroxysmal atrial fibrillation (AF) and age and sex matched controls undergoing CMR225 T2DM, 75 controls
- Exposure
- T2DM with vs without paroxysmal AF vs controls
- Controlsn = 75reference
- Outcome
- LV global strains (PS, PSSR, PDSR)
Methodological detailsCMR feature tracking, age and sex matched controls
- CMR feature tracking
- Age and sex matched controls
Main finding
As reported in the abstract
- Left ventricular (LV) peak strain (PS)-radial, PS-longitudinal and PDSR-radial declined successively from controls through T2DM(AF-) to T2DM(AF+)
- all p < 0.001
- LV PS-circumferential, PSSR-radial and PDSR-circumferential decreased in T2DM(AF+) vs controls but preserved in T2DM(AF-)
- all p < 0.001
Observational data: associations, not effects.
Further findings
AF independently associated with worsening LV strain (multivariable linear regression, T2DM)
- PS-longitudinal
- β = 2.218, p < 0.001
- PS-circumferential
- β = 3.948, p < 0.001
- PS-radial
- β = - 8.40, p < 0.001
- PSSR-radial
- β = - 0.345, p = 0.002
- PSSR-circumferential
- β = 0.101, p = 0.014
- PDSR-radial
- β = 0.359, p = 0.022
- PDSR-circumferential
- β = - 0.14, p = 0.003
Clinical characteristics
- T2DM(AF+) oldest, highest LV end-systolic volume index, lowest LVEF and eGFR vs controls and T2DM(AF-); shorter DM duration and lower HbA1c than T2DM(AF-)
Original publication
The worsening effect of paroxysmal atrial fibrillation on left ventricular function and deformation in type 2 diabetes mellitus patients: a 3.0 T cardiovascular magnetic resonance feature tracking study. Cardiovasc Diabetol. Published 6 March 2024. doi:10.
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