The differential effects of dyslipidemia status and triglyceride-glucose index on left ventricular global function and myocardial microcirculation in diabetic individuals: a cardiac magnetic resonance study
Main finding · LV GFIResult — go to the resultΒ coefficient - 0.159 95% CI - 0.281, - 0.032Authors' conclusion
Both dyslipidemia status and higher TyG index were associated with further deterioration of LV global function and myocardial microvascular function in the context of T2DM. The effects of dyslipidemia and a higher TyG index appear to be differential, which indicates that not only the amount of blood lipids and glucose but also the quality of blood lipids are therapeutic targets for preventing further myocardial damage.
Study context
- Population
- T2DM patients and controls who underwent cardiac magnetic resonance (CMR) examination226 T2DM, 72 controls
- Exposure
- T2DM with vs without dyslipidemia, and higher vs lower triglyceride-glucose (TyG) index, vs controls
- Controlsn = 72reference
- Outcome
- LV GFI
Methodological detailscardiac magnetic resonance
- Cardiac magnetic resonance
Main finding
As reported in the abstract
Β coefficient
- 0.159
95% CI - 0.281, - 0.032
P = 0.014
- Left ventricular (LV) global function index (GFI) sequentially decreased in controls, T2DM (DysL-) and T2DM (DysL+)
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | β coefficient (95% CI) | P value |
|---|---|---|
| LV remodeling indexHigher TyG index vs Lower TyG index · higher with higher TyG index | P = 0.002 | |
| LV remodeling indexTyG index · multivariable analysis; independent association | 0.152 (0.025–0.268) | P = 0.007 |
| LV perfusion indexMultivariable analysis; independent correlation | - 0.147 (- 0.272, - 0.024) | P = 0.02 |
| LV upslopeMultivariable analysis; independent correlation | - 0.200 (- 0.320, 0.083) | P = 0.001 |
| Time to maximum signal intensityMultivariable analysis; independent correlation | 0.141 (0.019–0.257) | P = 0.023 |
- LV perfusion index — Sequentially decreased in controls, T2DM (DysL-) and T2DM (DysL+)
- p < 0.001
- LV upslope — Sequentially decreased in controls, T2DM (DysL-) and T2DM (DysL+)
- p < 0.001
LV remodeling index
- No significant difference by dyslipidemia status; dyslipidemia status not independently associated
LV max signal intensity
- Sequentially decreased in controls, T2DM (DysL-) and T2DM (DysL+)
- P < 0.001
Original publication
The differential effects of dyslipidemia status and triglyceride-glucose index on left ventricular global function and myocardial microcirculation in diabetic individuals: a cardiac magnetic resonance study. Cardiovasc Diabetol. Published 19 September 2024. doi:10.
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