Impact of pretransplant T2DM on left ventricular deformation and myocardial perfusion in heart transplanted recipients: a 3.0 T cardiac magnetic resonance study
Authors' conclusion
In heart transplant recipients, pretransplant T2DM has a detrimental effect on subclinical left ventricular systolic function and could potentially impact myocardial microcirculation following HT.
Study context
- Population
- Heart transplant recipients with or without pretransplant T2D, and controls
- Participants
- 31 / 34 / 36
- Exposure
- Heart transplant (HT) recipients with vs without pretransplant T2D vs controls
- HT(DM+)n = 31
- HT(DM-)n = 34
- Controlsn = 36reference
- Outcome
- LV strain (GLS, GRS, GCS) and resting myocardial perfusion (TTM, MaxSI, Upslope)
Methodological detailscardiac magnetic resonance imaging, healthy controls
- Cardiac magnetic resonance imaging
- Healthy controls
Main finding
As reported in the abstract
- Correlation of HbA1c with longitudinal strain magnitude (all P < 0.05)
- r = - 0.399
- Correlation of HbA1c with radial strain magnitude (all P < 0.05)
- r = - 0.362
- Correlation of HbA1c with circumferential strain magnitude (all P < 0.05)
- r = - 0.389
- Correlation of HbA1c with TTM (P < 0.001)
- r = 0.485
- Pretransplant T2D, not perfusion indices, independent determinant of longitudinal strain, β (all P < 0.05)
- - 0.508
- Pretransplant T2D independent determinant of radial strain, β (all P < 0.05)
- - 0.370
- Pretransplant T2D independent determinant of circumferential strain, β (all P < 0.05)
- - 0.371
Observational data: associations, not effects.
Original publication
Impact of pretransplant T2DM on left ventricular deformation and myocardial perfusion in heart transplanted recipients: a 3.0 T cardiac magnetic resonance study. Cardiovasc Diabetol. Published 21 June 2024. doi:10.
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