Subclinical left ventricular deformation and microvascular dysfunction in T2DM patients with and without peripheral neuropathy: assessed by 3.0 T cardiac magnetic resonance imaging
Authors' conclusion
In patients with T2DM, there was more severe LV microvascular and myocardial dysfunction in patients with complicated DPN, and deteriorated subclinical LV systolic dysfunction was associated with impaired myocardial circulation.
Study context
- Population
- T2D patients with and without diabetic peripheral neuropathy (DPN) and matched controls who underwent cardiovascular MRI, October 2015–July 2022
- Participants
- 54 / 123 / 60
- Exposure
- T2D with DPN vs T2D without DPN vs controls
- DPNn = 54
- Without DPNn = 123
- Controlsn = 60reference
- Outcome
- LV myocardial perfusion at rest (upslope, TTM, max SI) and LV strains (GRS, GCS, GLS)
Methodological detailsage- and sex-matched controls, cardiac magnetic resonance imaging
- Age- and sex-matched controls
- Cardiac magnetic resonance imaging
Main finding
As reported in the abstract
LV GLS, upslope and max SI
- Left ventricular (LV) GLS, upslope and max SI significantly deteriorated from controls, through patients without DPN, to patients with DPN (all P < 0.001)
- Vs controls, TTM increased and LV GRS and GCS decreased in both patient groups (all P < 0.05)
Observational data: associations, not effects.
Further findings
Multivariable regression: DPN and upslope, max SI, LV GLS
- DPN independently associated with reduced upslope (β, p = 0.021)
- - 0.360
- DPN independently associated with reduced max SI (β, p = 0.031)
- - 2.503
- DPN independently associated with reduced LV GLS (β, p = 0.010)
- 1.113
- Multivariable analysis considering covariates
Multivariable analysis for LV GLS including perfusion indices
- DPN associated with LV GLS (β, p = 0.020)
- 1.057
- Upslope associated with LV GLS (β, p = 0.018)
- - 0.870
Original publication
Subclinical left ventricular deformation and microvascular dysfunction in T2DM patients with and without peripheral neuropathy: assessed by 3.0 T cardiac magnetic resonance imaging. Cardiovasc Diabetol. Published 21 September 2023. doi:10.
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