Myocardial interstitial fibrosis and subclinical left ventricular systolic dysfunction in type 2 diabetes mellitus patients with obesity: a 3.0 T MRI study
Authors' conclusion
In patients with T2DM, there was more severe myocardial interstitial fibrosis and subclinical LV systolic dysfunction in patients with obesity, and increased myocardial fibrosis is independently associated with impaired LV systolic function. These results indicate the potential clinical significance of weight management in T2DM patients with obesity.
Study context
- Population
- Patients with T2D with and without obesity and matched lean healthy controls undergoing cardiac MRI
- Participants
- 81 / 48 / 40
- Exposure
- T2D with obesity vs T2D without obesity vs lean healthy controls
- T2DM patients without obesityn = 81
- Patients with obesityn = 48
- Controlsn = 40reference
- Outcome
- Myocardial interstitial fibrosis (ECV) and LV systolic strain (GRS, GCS, GLS) by 3-D feature tracking
Methodological detailsmatched lean healthy controls
- Matched lean healthy controls
Main finding
As reported in the abstract
Obesity independently associated with extracellular volume (ECV) in T2D (multivariable linear regression)
β = 2.147
p = 0.006
Obesity independently associated with left ventricular (LV) GRS
β = - 3.427
p = 0.019
Obesity independently associated with LV GLS
β = 1.408
p = 0.001
Observational data: associations, not effects.
Further findings
LV GLS with ECV included in regression
- Obesity independently associated with LV GLS
- β = 1.540, p < 0.001
- ECV independently associated with LV GLS
- β = 0.118, p = 0.019
Original publication
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