Association of diabetes mellitus and glycemic control with left ventricular function and deformation in patients after acute myocardial infarction: a 3 T cardiac magnetic resonance study
Authors' conclusion
DM has an additive deleterious effect on LV function and deformation in patients after acute MI, and HbA1c was independently associated with impaired LV myocardial strain.
Study context
- Population
- Patients after acute myocardial infarction (MI) with or without diabetes mellitus (DM), and control subjects, who underwent cardiac MRI
- Participants
- 113 / 95 / 71
- Exposure
- MI with DM vs MI without DM vs controls
- MI (DM-)n = 113
- MI (DM+)n = 95
- Controln = 71reference
- Outcome
- LV global peak strains in radial, circumferential and longitudinal directions
Methodological detailsmultivariable linear regression analyses
- Multivariable linear regression analyses
Main finding
As reported in the abstract
LV global peak strains
- LV global peak strains progressively declined from control to MI(DM-) to MI(DM+)
- all p < 0.05
- DM independent determinant of impaired LV global peak strain in radial, circumferential and longitudinal directions after acute MI (β)
- - 0.166, 0.164 and 0.262, both p < 0.05
Observational data: associations, not effects.
Further findings
LV volumes and ejection fraction
- Both MI (DM-) and MI (DM+) had higher LV end-diastolic and end-systolic volume index and lower LV ejection fraction vs controls
Subgroup by glycemic control in MI (DM+) (HbA1c < 7.0% vs ≥ 7.0%)
- LV global radial and longitudinal PS worse with poor vs good glycemic control
- all p < 0.05
HbA1c and LV strain in MI (DM+)
- HbA1c independently associated with decreased LV global radial PS (β)
- - 0.209, p = 0.025
- HbA1c independently associated with decreased LV global longitudinal PS (β)
- 0.221, p = 0.010
Original publication
Association of diabetes mellitus and glycemic control with left ventricular function and deformation in patients after acute myocardial infarction: a 3 T cardiac magnetic resonance study. Cardiovasc Diabetol. Published 11 March 2023. doi:10.
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