Preserved Ratio Impaired Spirometry, Metabolomics, and the Risk of Type 2 Diabetes
Main finding · Incident T2DResult — go to the resultMore likely to develop T2D 47% 95% CI 33%–63%Authors' conclusion
Our study revealed the association of PRISm with T2D risk and the potential roles of circulating metabolites in mediating this association.
Study context
- Population
- Individuals without diabetes at baseline, UK Biobank
- Participants
- 72,683 individuals
- Exposure
- Preserved ratio impaired spirometry (PRISm) vs normal spirometry
- PRISmn = 8,394
- Normal spirometryn = 64,289reference
- Outcome
- Incident T2D
- Follow-up
- Median 12.06 years
Methodological detailsUK Biobank, mediation analysis
- UK Biobank
- Mediation analysis
Main finding
As reported in the abstract
More likely to develop T2D
47%
95% CI 33%–63%
- Participants who developed T2D
- 2513
Observational data: associations, not effects.
Further findings
Metabolite mediation of PRISm–T2D association
- Metabolites with significant mediation effects (false discovery rate <0.05)
- 121
- Mediation proportion: glycoprotein acetyls
- 11.91% (95% CI 8.76%-16.58%)
- Mediation proportion: cholesteryl esters in large high-density lipoprotein (HDL)
- 11.04% (95% CI 7.34%-15.55%)
- Mediation proportion: degree of unsaturation
- 10.36% (95% CI 7.34%-14.71%)
- Mediation proportion: cholesterol in large HDL
- 9.87% (95% CI 6.78%-14.09%)
- Mediation proportion: cholesteryl esters in very large HDL
- 9.51% (95% CI 6.33%-14.05%)
- 11 principal components (95% variance of metabolic signatures): proportion of relation accounted for
- 25.47% (95% CI 20.83%-32.19%)
Original publication
Preserved Ratio Impaired Spirometry, Metabolomics, and the Risk of Type 2 Diabetes. J Clin Endocrinol Metab. Published 10 March 2023. doi:10.
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