Diabetes mellitus is associated with low exercise capacity and impaired peripheral vasodilation in patients with heart failure − a propensity score-matched study
Authors' conclusion
Diabetes is associated with a reduced exercise capacity in patients with HF. Most predictors of lower exercise capacity in HF are similar regardless of DM except impaired vascular function and lower HDL cholesterol which predict lower exercise capacity only in those with DM.
Study context
- Population
- Patients with chronic heart failure (HF) in SICA-HF, matched on age, sex and HF severity variables
- Participants
- 615 patients231 matched pairs
- Exposure
- T2D vs no diabetes mellitus (DM) in patients with HF
- DMn = 231
- No DMn = 231reference
- Outcome
- Exercise capacity (peak VO2)
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
Peak VO2
P = 0.005
Observational data: associations, not effects.
Further findings
| Outcome | DM | No DM |
|---|---|---|
| Forearm blood flow reserve (per 1 ml/min/100 ml increase) and lower exercise capacity (peak VO2 ≤ 16.6 ml/min/kg) | ||
| OR | 0.92 (95 % CI 0.85-0.98; p = 0.014) | 0.98 (95 % CI 0.93-1.02) |
Forearm blood flow reserve (per 1 ml/min/100 ml increase) and lower exercise capacity (peak VO2 ≤ 16.6 ml/min/kg)
- A similar heterogeneity was also observed for HDL-C
Original publication
Diabetes mellitus is associated with low exercise capacity and impaired peripheral vasodilation in patients with heart failure − a propensity score-matched study. Diabetes Res Clin Pract. Published 19 September 2024. doi:10.
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