Association between atherogenic index of plasma and new-onset stroke in individuals with different glucose metabolism status: insights from China Health and Retirement Longitudinal Study (CHARLS)
Authors' conclusion
An increase in baseline AIP levels was significantly associated with the risk of stroke in middle-aged and elderly individuals, and exhibited distinct characteristics depending on the individual's glucose metabolism status.
Study context
- Population
- Participants aged ≥45 years without history of stroke, China Health and Retirement Longitudinal Study (CHARLS); Atherogenic index of plasma (AIP) = log[TG (mg/dL)/HDL-C (mg/dL)]
- Participants
- 8,727 participants
- Exposure
- AIP quartiles Q2, Q3, Q4 vs Q1
- Outcome
- New-onset stroke events
- Follow-up
- Average 8.72 years
Methodological detailspopulation-based, multivariate Cox proportional hazard models, restricted cubic spline analysis
- Population-based
- Multivariate Cox proportional hazard models
- Restricted cubic spline analysis
Main finding
As reported in the abstract
New-onset stroke, all participants
Each group vs Q1Hazard ratio (95% CI)
Q2
1.34(1.05–1.71)
Q3
1.52(1.19–1.93)
Q4
1.84(1.45–2.34)
- First stroke event
- 734 participants (8.4%)
- Kaplan-Meier: significant difference in stroke occurrence among AIP groups in all participants
- P < 0.05
Observational data: associations, not effects.
Further findings
Stroke by AIP, prediabetes mellitus (Pre-DM) and diabetes mellitus (DM) subgroups
- Kaplan-Meier: significant difference in stroke occurrence among AIP groups in Pre-DM and DM
- P < 0.05
- High AIP linked to increased stroke risk in pre-diabetic and diabetic participants across all three Cox models
Stroke by AIP, normal glucose regulation (NGR) subgroup
- Association not observed in participants with normal glucose regulation (NGR)
- P > 0.05
Restricted cubic spline
- Higher baseline AIP associated with higher HRs for stroke in all participants and those with glucose metabolism disorders
Original publication
Association between atherogenic index of plasma and new-onset stroke in individuals with different glucose metabolism status: insights from CHARLS. Cardiovasc Diabetol. Published 21 June 2024. doi:10.
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