Additive effect of metabolic dysfunction-associated fatty liver disease on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T cardiac magnetic resonance feature tracking study
Authors' conclusion
This study thoroughly compared CMR parameters in T2DM patients with and without MAFLD, uncovering MAFLD's adverse impact on LV function and deformation in T2DM patients. These findings highlight the critical need for early detection and comprehensive management of cardiac function in T2DM patients with MAFLD.
Study context
- Population
- T2D patients with and without metabolic-associated fatty liver disease (MAFLD) and matched normal controls, June 2015–March 2022261 T2D patients
- Exposure
- T2D with MAFLD vs T2D without MAFLD vs normal controls
- Outcome
- Cardiac magnetic resonance (CMR)-derived LV function and global strain parameters
Methodological detailscardiac magnetic resonance feature tracking, single medical center, matched normal controls
- Cardiac magnetic resonance feature tracking
- Single medical center
- Matched normal controls
Main finding
As reported in the abstract
- Progressive deterioration in LV functional parameters across controls, T2D without MAFLD and T2D with MAFLD: significant increases in left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), left ventricular mass index (LVMI) and decreases in left ventricular ejection fraction (LVEF) and left ventricular global function index (LVGFI)
- Significant reductions in absolute GRPS, GCPS and GLPS, and in PSSR and peak diastolic strain rates (PDSR) among the three groups
- MAFLD an independent predictor of LVEF, LVMI, LVGFI, GRPS, GCPS and GLPS in multivariate linear analysis
Observational data: associations, not effects.
Further findings
Late gadolinium enhancement
P = 0.003
MAFLD severity
- Escalating MAFLD severity associated with numerical deterioration in LV function and global strain
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Additive effect of metabolic dysfunction-associated fatty liver disease on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T cardiac magnetic resonance feature tracking study. Cardiovasc Diabetol. Published 27 August 2024. doi:10.
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