Adiposity modifies the association between heart failure risk and glucose metabolic disorder in older individuals: a community-based prospective cohort study
Authors' conclusion
Adiposity attenuated the association of glucose metabolic disorder with incident HF. The results also showed that WHR may be an appropriate indicator for evaluating adiposity in older individuals. Adiposity-associated metabolic activities may have a bridging role in the process of adiposity attenuating the association between glucose metabolic disorder and incident HF.
Study context
- Population
- Older community participants aged ≥60 years; adiposity assessed by body mass index (BMI), waist-to-hip ratio (WHR) and visceral fat area (VFA)
- Participants
- 13,251 participants
- Exposure
- Prediabetes, uncontrolled diabetes and well-controlled diabetes vs euglycemia
- Outcome
- First occurrence of HF
- Follow-up
- Average 10.9 years
Methodological detailscommunity-based
- Community-based
Main finding
As reported in the abstract
- Incident heart failure (HF) events
- 1,138
Observational data: associations, not effects.
Further findings
Population attributable risk % for WHR-defined central obesity, incident HF
Interaction of adiposity measures with glucose metabolic disorder on incident HF
- Adiposity measures, especially WHR, showed significant interaction
- all Padj.<0.001
Adiposity-associated metabolic activities (adiponectin-to-leptin ratio (ALR), homeostatic model assessment of insulin resistance (HOMA-IR), TyG)
- ALR negatively, HOMA-IR and TyG positively associated with BMI, WHR, VFA and incident HF
- all Padj.<0.05
- ALR, HOMA-IR and TyG mediated associations of BMI, WHR and VFA with incident HF
- all Padj.<0.05
Original publication
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