Impact of left ventricular dilatation on biventricular function and deformation in diabetes mellitus with reduced ejection fraction: a cardiac magnetic resonance (CMR) feature tracking study
Authors' conclusion
In DM patients with reduced LVEF, LV dilatation was associated with biventricular dysfunction and deformation injury. LV dilatation was found to be independently associated with impaired LVGCS, the further decrease of LVGCS in DM patients with reduced LVEF.
Study context
- Population
- Patients with clinically diagnosed diabetes mellitus (DM) who underwent CMR, September 2017 to March 2025
- Participants
- 265 patients
- Exposure
- DM with reduced left ventricular ejection fraction (LVEF) with vs without left ventricular (LV) dilatation, vs DM with preserved LVEF
- DMpEFn = 122reference
- DMrEF-NLVDn = 51
- DMrEF-DCMn = 92
- Outcome
- Biventricular global strains
Methodological detailsCMR feature tracking, single-centre
- CMR feature tracking
- Single-centre
Main finding
As reported in the abstract
- LV global strains progressively declined from DMpEF to DMrEF-NLVD to DMrEF-DCM
- all p < 0.001
- RV global strains more impaired in DMrEF-DCM and DMrEF-NLVD vs DMpEF
- all p < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | DMrEF-NLVD | DMrEF-DCM | P value |
|---|---|---|---|
| RVGCSDMrEF-DCM vs DMrEF-NLVD · decreased RVGCS with DMrEF-DCM | - 8.89 ± 4.15 | - 6.18 ± 3.52 | P < 0.001 |
Independent association of LV dilatation with LVGCS in DM with reduced LVEF (multivariable linear regression)
- LV dilatation independently associated with reduced LVGCS, β
- 0.176 (p = 0.009)
Original publication
Impact of left ventricular dilatation on biventricular function and deformation in diabetes mellitus with reduced ejection fraction: a CMR feature tracking study. Cardiovasc Diabetol. Published 18 November 2025. doi:10.
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