The right ventricular dysfunction and ventricular interdependence in patients with diabetes mellitus (DM): assessment using cardiac MR feature tracking
Authors' conclusion
In the patients with DM and preserved LVEF, the difference in RVGLS between DM and normal controls was totally mediated by LVGLS. Although there were partly mediating effects of LVGLS and LVGCS, the decrease in RVGCS might be directly affected by the DM.
Study context
- Population
- Patients with DM and preserved left ventricular ejection fraction (LVEF) who underwent cardiac MR, December 2016 to February 2022, single hospital
- Exposure
- DM vs normal controls
- DMn = 148
- Normal controlsn = Fifty-fourreference
- Outcome
- RV global strains
Methodological detailsconsecutive recruitment, cardiac MR feature tracking, mediation analysis
- Consecutive recruitment
- Cardiac MR feature tracking
- Mediation analysis
Main finding
As reported in the abstract
- DM vs Normal controls: P = 0.001
- DM vs Normal controls: P = 0.011
- DM vs Normal controls: P = 0.743
Observational data: associations, not effects.
Further findings
Mediation of right ventricular (RV) strain differences by LV strain
- RVGLS difference totally mediated by LVGLS
- 0.655 (indirect effect; bootstrapped 95% CI 0.138-0.265)
- RVGCS difference partly mediated by LVGLS
- 0.336 (indirect effect; bootstrapped 95% CI 0.002-0.820)
- RVGCS difference partly mediated by LVGCS
- 0.368 (indirect effect; bootstrapped 95% CI 0.028-0.855)
Original publication
The right ventricular dysfunction and ventricular interdependence in patients with DM: assessment using cardiac MR feature tracking. Cardiovasc Diabetol. Published 21 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →