The right ventricular dysfunction and ventricular interdependence in patients with T2DM and aortic regurgitation: an assessment using CMR feature tracking
Authors' conclusion
AR can exacerbate RV dysfunction in patients with T2DM, which may be associated with the superimposed strain injury of the left ventricle and interventricular septum. The RV longitudinal and circumferential strains are important indicators of cardiac injury in T2DM and AR. The unfavorable LV-RV interdependence supports that while focusing on improving LV function, RV dysfunction should be monitored and treated in order to slow the progression of the disease and the onset of adverse outcomes.
Study context
- Population
- Patients with T2DM with or without aortic regurgitation, and healthy controls
- Participants
- 88 / 229 / 122
- Exposure
- T2DM with aortic regurgitation (AR) vs T2DM without AR vs healthy controls
- T2DM (AR+)n = 88
- T2DM (AR-)n = 229
- Controlsn = 122reference
- Outcome
- Biventricular global radial, circumferential and longitudinal peak strain (GRS, GCS, GLS) by cardiac magnetic resonance feature tracking (CMR-FT)
Methodological detailsCMR feature tracking
- CMR feature tracking
Main finding
As reported in the abstract
- Right ventricular (RV) GLS, left ventricular (LV) global radial strain (GRS), LV global circumferential strain (GCS), LV GLS, interventricular septal (IVS) GRS and IVS GCS decreased gradually from controls through T2DM (AR-) to T2DM (AR+)
- IVS GLS lower in T2DM (AR-) and T2DM (AR+) than controls
Observational data: associations, not effects.
Further findings
Independent associations (backward stepwise multivariate linear regression)
- AR independently associated with LV GRS, LV GCS, LV GLS, RV GCS and RV GLS
- With AR and LV GLS in the model, AR and LV GLS independently associated with RV GLS
Original publication
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