The impact of diabetes mellitus on cardiac function assessed by magnetic resonance imaging in patients with hypertrophic cardiomyopathy
Authors' conclusion
Diabetes has adverse effects on LV and LA function in HCM patients, which may be important contributors to severe manifestations and outcomes in those patients. The present study strengthened the evidence of the prevention and management of diabetes in HCM patients.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) with or without coexisting DMmatched controls
- Comparison
- HCM with DM vs isolated HCM controls
- HCM-DMn = 45
- Outcome
- LV and LA structure and function on cardiac MRI
Methodological detailsmatched on maximal wall thickness, age and gender, cardiac MRI feature tracking strain analysis
- Matched on maximal wall thickness, age and gender
- Cardiac MRI feature tracking strain analysis
Main finding
As reported in the abstract
- HCM-DM vs Isolated HCM controls: all P < 0.05
- HCM-DM vs Isolated HCM controls: all P < 0.05
Observational data: associations, not effects.
Further findings
Association of DM with left ventricular (LV) function, all HCM patients (multivariable linear regression)
- DM independently associated with low LV ejection fraction (β; P < 0.001)
- - 6.05
- DM independently associated with impaired global longitudinal strain (β; P = 0.007)
- 1.40
Myocardial fibrosis by late gadolinium enhancement as predictor of LV/LA strain
- LV global radial strain (β; P = 0.008)
- - 45.81
- LV global circumferential strain (β; P = 0.003)
- 18.25
- LA reservoir strain (β; P < 0.001)
- - 59.20
- LA reservoir strain rate (β; P = 0.002)
- - 2.90
- More myocardial fibrosis by LGE in HCM-DM vs isolated HCM controls
- Independent predictor
Original publication
The impact of diabetes mellitus on cardiac function assessed by magnetic resonance imaging in patients with hypertrophic cardiomyopathy. Cardiovasc Diabetol. Published 8 August 2024. doi:10.
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