Effect of SGLT2 inhibitors on cardiac structure and function assessed by cardiac magnetic resonance: a systematic review and meta-analysis
Authors' conclusion
SGLT2i are associated with reductions in LV volumes and mass in line with an overall favorable reverse remodeling effects as assessed by CMR.
Study context
- Population
- Patients treated with SGLT2i with cardiac magnetic resonance (CMR) assessment of cardiac structure and function; databases searched through April 30, 2025
- Participants
- 1,008 patients23 studies
- Comparison
- SGLT2i treatment: pooled mean changes in CMR parameters
- Outcome
- Pooled mean changes in CMR parameters (LV and RV volumes, mass, function, stroke volume, global longitudinal strain, left atrial volume, tissue characterization)
Methodological detailsrandom-effects models, meta-regression, sensitivity analyses
- Random-effects models
- Meta-regression
- Sensitivity analyses
Pooled result
As reported in the abstract
CMR changes with SGLT2i
Mean change in LV end-diastolic volume, mL (95% CI)P value
SGLT2i
- 7.10(−13.01 to - 1.19)
P = 0.023Mean change in LV mass, g (95% CI)P value
SGLT2i
- 4.24(−7.88 to - 0.60)
P = 0.027Mean change in epicardial adipose tissue, ml (95% CI)P value
SGLT2i
−4.94(−9.06 to −0.82)
P = 0.019Further pooled results
Left ventricular (LV) stroke volume, subgroup with reduced LV ejection fraction
- Improvement in LV stroke volume in patients with reduced LV ejection fraction
Meta-regression
- No significant effect of age, male sex or diabetes prevalence on pooled estimates
Original publication
Effect of SGLT2 inhibitors on cardiac structure and function assessed by cardiac magnetic resonance: a systematic review and meta-analysis. Cardiovasc Diabetol. Published 21 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →