Very‐low‐calorie diet‐based intensive lifestyle intervention for remission of type 2 diabetes: Real‐world experience in a South Asian population
Authors' conclusion
VDRP is effective in achieving T2D remission amongst Sri Lankan adults with recently diagnosed T2D and obesity. Over half of the participants followed the programme and over 75% would recommend it to others, indicating good acceptability.
Study context
- Population
- Sri Lankan adults (>18 years) with T2D for <3 years and BMI over 25 kg/m²; mean age 38.4 years, men 68%, mean baseline HbA1c 86.9 mmol/mol87 followed programme
- Participants
- 170 adults
- Exposure
- Very Low-calorie Diet (VLCD)-based Diabetes Remission Programme followers vs non-followers
- VDRP followersn = 87
- VDRP non-followersn = 83reference
- Outcome
- Diabetes remission: HbA1c <6.5% at least 3 months after stopping glucose-lowering medications
Methodological detailsreal-world, single diabetes practice
- Real-world
- Single diabetes practice
Main finding
As reported in the abstract
Achieving DR (HbA1c <6.5% ≥3 months after stopping glucose-lowering medications)
Adjusted hazard ratio
9.3
95% CI 2.2–16.4
P = 0.002
Events by group
Between Followed VDRP and Did not follow VDRP
aHR 9.3 (95% CI 2.2–16.4); P = 0.002
Observational data: associations, not effects.
Further findings
Events
| Outcome | VDRP followers | VDRP non-followers |
|---|---|---|
| Normoglycaemia (HbA1c <6.5%) while continuing glucose-lowering medication | 20 | 20 |
- Normoglycaemia (HbA1c <6.5%) while continuing glucose-lowering medication: 20/87 vs 20/85
Acceptability
- Followed the programme
- 87 (51%)
- Reason for not following: too restrictive dietary quantity
- 92%
- Reason for not following: difficulties finding recommended food items
- 67%
- Would recommend VDRP to others
- 79%
Original publication
Very‐low‐calorie diet‐based intensive lifestyle intervention for remission of type 2 diabetes: Real‐world experience in a South Asian population. Diabet Med. Published 8 August 2024. doi:10.
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