Risk of progression from pre‐diabetes to type 2 diabetes in a large UK adult cohort
Authors' conclusion
South Asian or Mixed-Race individuals and people with social deprivation had an increased risk of progression from pre-diabetes to type 2 diabetes. Clinicians need to recognise the differing risk across their patient populations to implement appropriate prevention strategies.
Study context
- Population
- Adults aged ≥18 years with pre-diabetes (HbA1c 42 mmol/mol (6.0%) to 48 mmol/mol (6.5%)), UK The Health Improvement Network (THIN) database
- Participants
- 397,853 adults
- Exposure
- Exposure categories and risk of progression from pre-diabetes to T2D
- Outcome
- Progression from pre-diabetes to T2D
Methodological detailsTHIN database, Cox proportional hazards regression
- THIN database
- Cox proportional hazards regression
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)
South Asianvs White European
1.31(1.26–1.37)
Mixed-Racevs White European
1.22(1.11–1.33)
Most deprivedvs Least deprived
1.17(1.14–1.20)
18 to <30 yearsvs 40 to <65 years
0.63(0.58–0.69)
≥65 yearsvs 40 to <65 years
0.85(0.84–0.87)
Observational data: associations, not effects.
Original publication
Risk of progression from pre‐diabetes to type 2 diabetes in a large UK adult cohort. Diabet Med. Published 11 November 2022. doi:10.
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