The Association Between Race/Ethnicity and Risk of Type 2 Diabetes in Women Varies by BMI: A Pooled Analysis of Individual Data From 15 Cohort Studies
Pooled result · T2D risk, BMI-adjusted, vs White womenResult — go to the resultHazard ratio 4.13 95% CI 3.78–4.51Authors' conclusion
South/Southeast Asian women have a markedly elevated risk of type 2 diabetes, further amplified by modestly higher BMI, highlighting the need for ethnicity-specific diabetes prevention strategies for women.
Study context
- Population
- Women in 15 cohort studies
- Participants
- 730,408 women15 cohort studies
- Comparison
- Race/ethnicity vs White women
- Outcome
- T2D risk by race/ethnicity and its interaction with BMI
Methodological detailsindividual-level data, Cox proportional hazards models with study as a random effect
- Individual-level data
- Cox proportional hazards models with study as a random effect
Pooled result
T2D risk, BMI-adjusted, vs White women
Hazard ratio
4.13
95% CI 3.78–4.51
South/Southeast Asianvs White
HR 4.13 (95% CI 3.78–4.51)
As reported in the abstract
Further pooled results
Cumulative incidence of T2D · by age 70 · highest among South/Southeast Asian and Black women
Baseline obesity (BMI ≥27.5 kg/m²) South/Southeast Asian 40.0%
Baseline obesity (BMI ≥30 kg/m²) Black 45.6%
| Outcome | HR (CI) | |
|---|---|---|
| Joint race/ethnicity–BMI: T2D risk vs White women with BMI 18.5-22.9 kg/m²South/Southeast Asian, BMI 27.5-29.9 kg/m²vs White, BMI 18.5-22.9 kg/m² | 23.17 (19.21–27.95) | |
| Joint race/ethnicity–BMI: T2D risk vs White women with BMI 18.5-22.9 kg/m²South/Southeast Asian, BMI ≥30 kg/m²vs White, BMI 18.5-22.9 kg/m² | 35.52 (30.57–41.28) | |
| 0.050.21520Hazard ratio (log scale) |
Overall T2D incidence
- Women diagnosed with T2D
- 37,329 (5.1%)
Joint race/ethnicity–BMI: T2D risk vs White women with BMI 18.5-22.9 kg/m²
- South/Southeast Asian women with BMI ≥23 kg/m² had substantially greater risk than other groups with the same BMI
Original publication
The Association Between Race/Ethnicity and Risk of Type 2 Diabetes in Women Varies by BMI: A Pooled Analysis of Individual Data From 15 Cohort Studies. Diabetes Care. Published 2 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →