Pre-Prediabetes: Insulin Resistance Is Associated With Cardiometabolic Risk in Nonobese Patients (STOP DIABETES)
Authors' conclusion
Approximately 1 in 4 nonobese patients in this population with normal fasting glucose and HbA1c were IR. In these nonobese participants, IR was associated with multiple indicators of dysglycemia and cardiometabolic risk.
Study context
- Population
- Nonobese, nonprediabetic patients from the STOP DIABETES study: normal FPG, body mass index (BMI) <30, hemoglobin A1c (HbA1c) <5.7%; all received an OGTTof 1860 screened
- Participants
- 624 participants
- Exposure
- Insulin-resistant (insulin resistance (IR)) vs matched insulin-sensitive (IS) nonobese, nonprediabetic individuals
- IRn = 151
- ISn = 151reference
- Outcome
- Glycemic and cardiometabolic risk markers
Methodological detailsmatched for BMI, sex, and age
- Matched for BMI, sex, and age
Main finding
As reported in the abstract
- IR vs matched IS: increased 60-min plasma glucose and % with 60-min plasma glucose >155 mg/dL; increased 120-min plasma glucose
- IR vs matched IS: unrecognized impaired glucose tolerance and T2D; decreased disposition index
- IR vs matched IS: increased systolic and diastolic blood pressure
- IR vs matched IS: elevated TG, reduced HDL-C, increased TG/high-density lipoprotein (HDL) ratio and high-sensitivity C-reactive protein
Observational data: associations, not effects.
Further findings
- Prevalence of IR
- 151 · events
- Prevalence of IR: IR defined as Matsuda index <25th percentile among 624
Carotid plaque (presence, size, number)
- Presence, size and number of carotid plaques greater in IR
- Measured in 65 IR and 76 IS individuals
Original publication
Pre-Prediabetes: Insulin Resistance Is Associated With Cardiometabolic Risk in Nonobese Patients (STOP DIABETES). J Clin Endocrinol Metab. Published 7 August 2024. doi:10.
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