Insulin Sensitive Patients With Impaired Glucose Tolerance: Physiologic and Metabolic Characterization ( STOP DIABETES )
Authors' conclusion
Approximately one third of patients from the STOP DIABETES study demonstrate impaired glucose tolerance despite having normal insulin sensitivity. This IS-IGT group had significantly less metabolic dyslipidaemia, less hypertension, better beta cell function and increased insulin clearance compared to insulin resistant IGT patients.
Study context
- Population
- Patients with impaired glucose tolerance (IGT) from the STOP DIABETES trial
- Participants
- 107 / 222 / 574
- Comparison
- IS-IGT vs IR-IGT
- IS-IGTn = 107
- IR-IGTn = 222reference
- IS-NGTn = 574
Methodological detailscross-sectional comparison
- Cross-sectional comparison
Primary result
As reported in the abstract
- IS-IGT had higher plasma HDL and lower BMI, plasma TG, TG/HDL ratio, hs-CRP vs IR-IGT (all p < 0.001)
- IS-IGT had normal blood pressure vs IR-IGT (p < 0.01)
- IS-IGT developed IGT with a higher disposition index (p < 0.0001)
Further findings
| Outcome | IS-IGT | IR-IGT | P value |
|---|---|---|---|
| Early insulinogenic indexIS-IGT vs IR-IGT | 10.5 ± 0.4 | 21.4 ± 0.5 | P < 0.0001 |
IS-IGT vs IS-NGT
- IS-IGT had reduced beta cell function and increased insulin clearance vs IS-NGT
Original publication
Insulin Sensitive Patients With Impaired Glucose Tolerance: Physiologic and Metabolic Characterization ( STOP DIABETES ). Diabetes Obes Metab. Published 13 April 2026. doi:10.
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