Dietary Fibre, Gut Microbiota and Cardiovascular Outcomes: Differential Associations by Diabetes Status in Multiethnic Cohorts
Authors' conclusion
The exploratory microbiota index reflects the interplay between fibre, gut health and cardiovascular outcomes
Study context
- Population
- Participants from four cohorts in three countries; gut microbiota data from two Chinese cohorts7,951 with microbiota data
- Participants
- 207,413 participants
- Exposure
- Higher vs lower dietary fibre intake, by diabetes status
- Outcome
- CVD mortality and MACE (non-fatal ischaemic heart disease, HF, stroke and cardiovascular deaths)
Methodological detailsmultiethnic, four cohorts in three countries
- Multiethnic
- Four cohorts in three countries
Main finding
As reported in the abstract
Dietary fibre intake (per SD) and CVD mortality and MACE risk, by diabetes status
Normoglycaemia or prediabetes: reduced cardiovascular disease (CVD) mortality per SD fibre
11% per SD
Normoglycaemia or prediabetes: reduced major adverse cardiovascular events (MACE) risk per SD fibre
6%-12% per SD
Observational data: associations, not effects.
Further findings
Exploratory fibre-related microbiota index and MACE risk
- Inversely associated with MACE across all diabetes statuses (risk reduction per SD)
- 17%-23%
- Index correlated with energy-adjusted fibre intake only in non-diabetic individuals
- Exploratory
Original publication
Dietary Fibre, Gut Microbiota and Cardiovascular Outcomes: Differential Associations by Diabetes Status in Multiethnic Cohorts. Diabetes Obes Metab. Published 13 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →