Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) dietary exposure is associated with an increased risk of type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC) cohort
Authors' conclusion
Results obtained in this large European prospective study indicate a positive and linear association between dietary intake of NDL-PCBs and risk of T2DM. This association remained consistent across various stratified and sensitivity analyses. Further studies are warranted to better understand the biological mechanisms underlying this association.
Study context
- Population
- Individuals of the EPIC cohort, recruited in 21 centers in 8 countries; dietary intake estimated from EPIC food consumption and European Food Safety Authority (EFSA) food contamination data
- Participants
- 318,416 individuals
- Exposure
- Higher vs lower estimated dietary intake of dioxins, dioxin-like polychlorinated biphenyls (DL-PCBs) and NDL-PCBs
- Outcome
- Incident T2D
- Follow-up
- Median 11.7 years
Methodological detailsmulticentre, 21 centers in eight countries, multivariable Cox regression
- Multicentre
- 21 centers in eight countries
- Multivariable Cox regression
Main finding
As reported in the abstract
Incident T2D by estimated dietary NDL-PCB intake
Hazard ratio (95 % CI)P value
Per 1 SD increment
1.03(1.01–1.04)
Q4vs Q1
1.15(1.08–1.22)
P < 0.001for trendObservational data: associations, not effects.
Further findings
Stratified and sensitivity analyses of NDL-PCB intake and T2D
- Results consistent when stratified by gender, BMI, country, median follow-up, or self-reported hypertension and hyperlipidemia, and when adjusting for fat intake
Dioxins+DL-PCBs intake and T2D
- No consistent association between dioxins+DL-PCBs intake and T2D risk
Original publication
Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) dietary exposure is associated with an increased risk of type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC) cohort. Diabetes Metab. Published 8 November 2024. doi:10.
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