Association between liver steatosis, fibrosis, and the onset of type 2 diabetes in overweight individuals: A fibroscan-based study in Southern Italy
Authors' conclusion
Elevated liver steatosis and fibrosis are both linked to type 2 diabetes, independent of traditional risk factors. These findings support screening for diabetes in individuals with significant steatosis and fibrosis and vice versa.
Study context
- Population
- Medication-free men and women with overweight or obesity (41.4 % male), Southern Italy
- Participants
- 164 men
- Exposure
- T2D vs no diabetes
- Diabetesn = 39
- Outcome
- Liver steatosis (CAP > 275 dBm)
Methodological detailsFibroscan-based
- Fibroscan-based
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Liver fibrosis (liver stiffness > 8.2 kPa)
P = 0.002
Mean CAP and kPa values
- Mean CAP significantly higher with diabetes
- P < 0.001
- Mean kPa significantly higher with diabetes
- P = 0.006
Independent association of CAP and liver stiffness with diabetes
- CAP with diabetes, MD 30.87
- P = 0.009
- Liver stiffness with diabetes, MD 2.454
- P = 0.006
- Independent of other variables
Liver steatosis and HOMA-IR
- Liver steatosis independently associated with elevated HOMA-IR
- P = 0.001
Original publication
Association between liver steatosis, fibrosis, and the onset of type 2 diabetes in overweight individuals: A fibroscan-based study in Southern Italy. Diabetes Res Clin Pract. Published 7 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →