Relationship of ultra-processed food consumption and new-onset chronic kidney diseases among participants with or without diabetes
Authors' conclusion
There was a significantly stronger positive association between UPF consumption and new-onset CKD in participants with diabetes compared with those without diabetes.
Study context
- Population
- UK Biobank participants free of chronic kidney disease (CKD) at baseline who provided 24-h dietary recalls4,058 new-onset CKD
- Participants
- 153,985 participants
- Exposure
- Ultra-processed foods (UPF) consumption and new-onset CKD, with vs without diabetes
- Outcome
- New-onset CKD (self-report and linkage with primary care, hospital admissions and death registry records)
- Follow-up
- Median 12.1 years
Methodological detailsUK Biobank, 24-h dietary recalls, NOVA classification
- UK Biobank
- 24-h dietary recalls
- NOVA classification
Main finding
As reported in the abstract
New-onset CKD per 10% increment in UPF consumption
- Total participants: aHR per 10% increment
- 1.04 (95% CI 1.01;1.06)
- With diabetes: aHR per 10% increment (1.05;1.17)
- 1.11
- Without diabetes: aHR per 10% increment (1.00;1.05)
- 1.03
- Association stronger with vs without diabetes: P-interaction
- P-interaction = 0.005
Observational data: associations, not effects.
Further findings
Effect modification by genetic risk of kidney diseases
- Genetic risks did not significantly modify the association with or without diabetes
- all P-interactions > 0.05
Original publication
Relationship of ultra-processed food consumption and new-onset chronic kidney diseases among participants with or without diabetes. Diabetes Metab. Published 6 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →