Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model
Authors' conclusion
Multifactorial management of cardiometabolic risk factors may have a substantial impact on CVD prevention, with cost savings in patients with T2D.
Study context
- Population
- Asian patients with T2D in the Joint Asia Diabetes Evaluation (JADE) Register, 11 Asian countries/jurisdictions; 53.4% men, 12.0% current smokers, mean age 57.6 (SD 11.8), HbA1c 7.96 (1.87), systolic BP 132.0 (17.4) mmHg, LDL-C 2.6 (0.95) mmol/L, BMI 26.2 (4.5) kg/m²
- Participants
- 103,958 patients
- Exposure
- Simulated attainment of multiple treatment targets vs baseline risk factor control
- Cardiovascular disease (CVD)n = 17,151
- non-CVDn = 86,807
- Outcome
- Incidence of fatal/non-fatal CVD (ischaemic heart disease and stroke) and associated healthcare costs
- Follow-up
- 3 years
Methodological detailsvalidated 'ABC' model, scenario-based, registry-based (JADE Register), 11 Asian countries/jurisdictions
- Validated 'ABC' model
- Scenario-based
- Registry-based (JADE Register)
- 11 Asian countries/jurisdictions
Main finding
As reported in the abstract
Estimated CVD incidence rate
CVD
61.60 per 1000-person-years
non-CVD
11.65 per 1000-PY
- Simulated achievement of all three ABC targets reduced incidence rates in the CVD group
- 35.1%-40.01% per 1000-PY
- Simulated achievement of all three ABC targets reduced incidence rates in the non-CVD group
- 30.2%-8.13% per 1000-PY
Observational data: associations, not effects.
Further findings
Achieved all three ABC targets at baseline
Simulated averted CVD events and cost savings in China · per year
- CVD events averted per year
- 1 177 682
- Potential saving
- US$ 11 292 823 476
Original publication
Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model. Diabetes Obes Metab. Published 13 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →