Estimated Glomerular Filtration Rate Change and Heart Failure Events With GLP ‐1 Receptor Agonists: A Meta‐Analysis and Meta‐Regression of Randomised Controlled Trials
Pooled result · Clinical HF eventsResult — go to the resultHazard ratio 0.86 95% CI 0.80–0.93Authors' conclusion
Across large-scale GLP-1RA trials, greater annualised eGFR improvement was associated with larger reductions in clinical HF events.
Study context
- Population
- Randomised, placebo-controlled GLP-1 RA trials enrolling ≥ 1000 adults with T2D and/or overweight or obesity, follow-up ≥1 year
- Participants
- 90,867 participants11 trials
- Comparison
- GLP-1 RA vs placebo
- Outcome
- Clinical HF events:
- Hospitalisation for HF
- With
- Without urgent HF visits
Methodological detailsrandom-effects meta-analysis, mixed-effects meta-regression, placebo-controlled trials, PubMed and Embase searched from inception to 29 January 2026
- Random-effects meta-analysis
- Mixed-effects meta-regression
- Placebo-controlled trials
- PubMed and Embase searched from inception to 29 January 2026
Pooled result
Clinical HF events
Hazard ratio
0.86
95% CI 0.80–0.93
P < 0.001
GLP-1RAsvs Placebo
HR 0.86 (95% CI 0.80–0.93); P < 0.001
As reported in the abstract
- Clinical heart failure (HF) events
- 2863
Further pooled results
Meta-regression: annualised estimated glomerular filtration rate (eGFR) improvement and HF risk reduction
- Annualised eGFR improvement significantly associated with greater HF risk reduction
- P = 0.009
- Each 1 mL/min/1.73 m²/year greater eGFR improvement: lower hazard of clinical HF events
- 21% (95% CI 7% to 32%)
- Trial level
Meta-regression: body weight, systolic blood pressure (SBP) and heart rate
- Changes in body weight, SBP and heart rate were not associated with HF risk reduction
Original publication
Estimated Glomerular Filtration Rate Change and Heart Failure Events With GLP ‐1 Receptor Agonists: A Meta‐Analysis and Meta‐Regression of Randomised Controlled Trials. Diabetes Obes Metab. Published 13 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →