Real-world evidence on health-related quality of life in patients with type 2 diabetes mellitus using sulphonylureas: An analysis of the Joint Asia Diabetes Evaluation (Joint Asian Diabetes Evaluation (JADE)) Register
Authors' conclusion
Demographic, physical and psychosocial-behavioural factors were associated with HRQoL in patients with T2DM. Our real-world data add to previous evidence that gliclazide is an effective OGLD, with most treated patients reporting good HRQoL. A plain language summary of this manuscript is available here.
Study context
- Population
- Adults with T2D from 11 Asian countries/regions enrolled in the JADE Register (2007–2019) with EQ-5D-3L data
- Participants
- 47,895 adults
- Exposure
- Oral glucose-lowering drugs (OGLDs) + lifestyle modifications vs lifestyle modifications only
- OGLD + lifestyle modifications (LSM)n = 42,813
- LSM onlyn = 5,082reference
- Outcome
- HRQoL (EQ-5D-3L) and associated factors
Methodological detailsprospectively enrolled register, 11 Asian countries/regions
- Prospectively enrolled register
- 11 Asian countries/regions
Main finding
As reported in the abstract
Mean EQ-5D-3L index score
Most affected EQ-5D-3L dimensions in OGLD + LSM: pain/discomfort
26.2%
Most affected EQ-5D-3L dimensions in OGLD + LSM: anxiety/depression
22.6%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HbA1c and HRQoL, gliclazide vs non-gliclazide SUs | P < 0.001 |
- HbA1c and health-related quality of life (HRQoL), gliclazide vs non-gliclazide SUs: lower HbA1c and better HRQoL in all dimensions with gliclazide
SU use among OGLD-treated
- Received SUs
- 60%
- Received gliclazide among SU users
- 47%
Original publication
Real-world evidence on health-related quality of life in patients with type 2 diabetes mellitus using sulphonylureas: An analysis of the Joint Asia Diabetes Evaluation (JADE) Register. Diabetes Res Clin Pract. Published 28 July 2023. doi:10.
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