Effects of diabetes mellitus on left ventricular function and deformation in patients with restrictive cardiomyopathies: a 3.0T cardiac magnetic resonance (CMR) feature tracking study
Authors' conclusion
DM may have an additive deleterious effect on LV dysfunction in patients with RCM, especially diastolic dysfunction in RCM patients, indicating the importance of early identification and initiation of treatment of DM in patients with RCM.
Study context
- Population
- Patients with restrictive cardiomyopathy, with or without diabetes mellitus (DM), and matched controls who underwent CMR
- Participants
- 136 / 46 / 66
- Exposure
- Restrictive cardiomyopathy (RCM) with DM vs RCM without DM vs controls
- RCM(DM-)n = 136
- RCM(DM+)n = 46
- Controln = 66reference
- Outcome
- LV global peak strain (radial, circumferential, longitudinal) and longitudinal PDSR
Methodological details3.0T CMR feature tracking, age- and sex-matched controls
- 3.0T CMR feature tracking
- Age- and sex-matched controls
Main finding
As reported in the abstract
- Left ventricular (LV) GPS in all three directions and longitudinal PDSR progressively declined from Control to RCM(DM-) to RCM(DM+)
- all p < 0.05
- DM independent determinant of impaired LV GPS radial, circumferential, longitudinal and longitudinal PDSR in RCM (β)
- - 0.217, 0.176, 0.253, and - 0.263, all p < 0.05
Observational data: associations, not effects.
Further findings
LV volumes and LVEF
- RCM(DM-) and RCM(DM+) had increased LV end-diastolic index and end-systolic volume index and decreased LVEF vs Control
Multiparameter combination including DM predicting decreased LV GLPS and longitudinal PDSR
- AUC for decreased LV GLPS
- 0.81(95% CI 0.75-0.87)
- AUC for decreased LV longitudinal PDSR
- 0.69 (95% CI 0.62-0.76)
Original publication
Effects of diabetes mellitus on left ventricular function and deformation in patients with restrictive cardiomyopathies: a 3.0T CMR feature tracking study. Cardiovasc Diabetol. Published 20 November 2023. doi:10.
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