The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T cardiac magnetic resonance (CMR) feature tracking study
Authors' conclusion
Anemia has additive deleterious effects on LV function and LV global strains in patients with T2DM. Regular detection and early intervention of anemia might be beneficial for T2DM patients.
Study context
- Population
- T2D patients with or without anemia and controls who underwent CMR236 T2D + 67 controls
- Exposure
- T2D with anemia vs T2D without anemia vs controls
- Controln = 67reference
- Outcome
- LV global radial, longitudinal and circumferential peak strain (GRPS, GLPS, GCPS)
Methodological detailscardiac magnetic resonance feature tracking
- Cardiac magnetic resonance feature tracking
Main finding
As reported in the abstract
LV global peak strains (all three directions)
- Left ventricular (LV) global peak strains in all three directions worsened successively from controls to T2D without anemia to T2D with anemia
- all p < 0.001
Observational data: associations, not effects.
Further findings
Baseline and LV function parameters
- T2D with anemia oldest, lowest hemoglobin (Hb) and eGFR, highest LV end-systolic volume index, end-diastolic volume index and LV mass index vs control and T2D without anemia
- all P ≤ 0.001
Factors associated with LV global strains (multivariable linear regression, T2D groups)
- Decrease in Hb independently associated with worsening global radial peak strain (GRPS)
- β = 0.237, p = 0.001
- Decrease in Hb independently associated with worsening GCPS
- β = 0.326, p < 0.001
- Decrease in Hb independently associated with worsening GLPS
- β = 0.265, p < 0.001
Original publication
The worsening effect of anemia on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T CMR feature tracking study. Cardiovasc Diabetol. Published 24 January 2023. doi:10.
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