The Interactive Effects of Sedentary Time, Physical Activity, and Fat Mass on Insulin Resistance in the Young Population
Authors' conclusion
Promoting LPA while decreasing body fat mass and ST may be considered crucial intervention targets to attenuate the risk of hyperinsulinemia and insulin resistance from childhood through young adulthood.
Study context
- Population
- Children from the Avon Longitudinal Study of Parents and Children, UK, followed from age 11 to 24 years, with ≥2 accelerometer measures (ages 11, 15, 24) and complete fasting glucose, insulin and homeostatic model assessment for insulin resistance (HOMA-IR) at ages 15, 17 and 24
- Participants
- 792 children
- Outcome
- Effects of cumulative sedentary time, light PA and MVPA on glucose, insulin and HOMA-IR
- Follow-up
- Ages 11–24 years
Methodological detailsobservational, accelerometer-measured movement behaviour, temporal path analyses
- Observational
- Accelerometer-measured movement behaviour
- Temporal path analyses
Main finding
As reported in the abstract
Hyperinsulinemia among participants with overweight/obesity · cumulative, ages 11-24 years
Cumulative sedentary time: increased odds of hyperinsulinemia, OR (95% CI), P
1.20
1.00–1.44P = .047
Cumulative light physical activity (PA): decreased odds of hyperinsulinemia, OR (95% CI), P
0.80
0.66–0.96P = .017
Observational data: associations, not effects.
Further findings
Insulin and cumulative MVPA, mediation by fat mass
- Cumulative MVPA inversely associated with insulin; after accounting for mediating fat mass, MVPA effect on lowering insulin decreased (nonsignificant)
- 58%
Temporal path analyses among participants with overweight/obesity · ages 15 to 24 years
- Higher glucose at 15 years associated with lower light PA and MVPA at 24 years
- Higher light PA at 15 years associated with lower insulin and HOMA-IR at 24 years and vice versa
Original publication
The Interactive Effects of Sedentary Time, Physical Activity, and Fat Mass on Insulin Resistance in the Young Population. J Clin Endocrinol Metab. Published 5 March 2024. doi:10.
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