Melatonin supplementation improves insulin resistance markers but not fasting glucose: a systematic review and meta-analysis of randomized controlled trials
Authors' conclusion
Melatonin supplementation did not significantly reduce fasting glucose but may improve markers of glycemic control and insulin sensitivity, suggesting a modulatory role in metabolic regulation.
Study context
- Population
- Adults in randomized controlled trials (RCTs) of melatonin supplementation reporting fasting glucose, HbA1c, fasting insulin or homeostatic model assessment of insulin resistance (HOMA-IR)31 RCTs
- Comparison
- Oral melatonin supplementation
- Outcome
- Fasting glucose
Methodological detailsrandom-effects model, meta-regression
- Random-effects model
- Meta-regression
Pooled result
As reported in the abstract
- No significant reduction in fasting glucose levels
- 27 studies
Further pooled results
- Improvements in HbA1c, fasting insulin and HOMA-IR
- HbA1c 9 studies; fasting insulin 7 studies; HOMA-IR 4 studies
Original publication
Melatonin supplementation improves insulin resistance markers but not fasting glucose: a systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. Published 1 May 2026. doi:10.
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