Multi-ancestry polygenic mechanisms of type 2 diabetes
An erratum to this article was published (Nat Med, Jul 2024 ↗)
Authors' conclusion
Thus, these multi-ancestry T2D genetic clusters encompass a broader range of biological mechanisms and provide preliminary insights to explain ancestry-associated differences in T2D risk profiles.
Study context
- Population
- Diverse populations in 37 published T2D GWAS (>1.4 million individuals); clusters assessed in two independent biobanks of diverse genetic ancestry37 GWAS, >1.4 million
- Participants
- 21,906 / 14,410 / 2,422 / 90,093 / 1,262
- Comparison
- African vs Admixed American vs East Asian vs European vs South Asian
- Africann = 21,906
- Admixed Americann = 14,410
- East Asiann = 2,422
- Europeann = 90,093reference
- South Asiann = 1,262
- Outcome
- Multi-ancestry T2D genetic clusters
Methodological detailsmulti-ancestry, soft clustering, meta-analysis of 37 published GWAS, validation in two independent biobanks
- Multi-ancestry
- Soft clustering
- Meta-analysis of 37 published GWAS
- Validation in two independent biobanks
Pooled result
As reported in the abstract
- Genetic clusters identified from 650 T2D-associated variants and 110 T2D-related traits
- 12
Further pooled results
BMI with equivalent T2D risk
- Body mass index (BMI) with equivalent T2D risk — East Asian equivalent BMI threshold after adjusting for cluster-specific genetic risk
- 28.5 (27.1-30.0) kg m-2
Original publication
Multi-ancestry polygenic mechanisms of type 2 diabetes. Nat Med. Published 5 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →