Genetic scores associated with favourable and unfavourable adiposity have consistent effect on metabolic profile and disease risk across diverse ethnic groups
Authors' conclusion
The study provides evidence that the genetic scores associated with favourable and unfavourable adiposity have consistent effects on metabolic profiles and disease risk across diverse ethnic groups. These findings deepen our understanding of distinct adiposity subtypes and their impact on metabolic health.
Study context
- Population
- Six populations in Pan-UKB GWAS: European, African (6636), American (980), Central/South Asian (8876), East Asian (2709), Middle Eastern (1599)six populations · European 420,531
- Comparison
- Favourable vs unfavourable adiposity genetic risk scores (GRS)
- Outcome
- Associations of favourable and unfavourable adiposity GRS with 39 adiposity-related outcomes
Methodological detailsPan-UKB GWAS summary statistics, multi-ancestry
- Pan-UKB GWAS summary statistics
- Multi-ancestry
Main finding
As reported in the abstract
Metabolic profile and disease risk
- Favourable adiposity GRS: lower T2D risk, lower liver enzymes, lower blood pressure, higher HDL-C, lower TG, higher apolipoprotein A, lower apolipoprotein B, higher testosterone, lower calcium and lower IGF-1, generally consistently across all populations
- Unfavourable adiposity GRS: higher T2D risk, higher random glucose, higher HbA1c, lower HDL-C, higher TG, higher liver enzymes, lower testosterone and higher C-reactive protein, generally consistently across all populations
Original publication
Genetic scores associated with favourable and unfavourable adiposity have consistent effect on metabolic profile and disease risk across diverse ethnic groups. Diabet Med. Published 6 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →