High Prevalence of A−β+ Ketosis-Prone Diabetes in Children with Type 2 Diabetes and Diabetic Ketoacidosis at Diagnosis: Evidence from the Rare and Atypical Diabetes Network (RADIANT)
Authors' conclusion
In children with a clinical phenotype of T2D and DKA at diagnosis, approximately half meet criteria for A-β+ KPD. They manifest the key characteristics of obesity, preserved β-cell function, male predominance, and potential to discontinue insulin therapy, similar to adults with A-β+ KPD.
Study context
- Population
- Children with T2D at a large academic hospital; mean age at diagnosis 13.7 ± 2.4 years, 63% female; 59% Hispanic, 29% African American
- Participants
- 716 children
- Exposure
- Children with vs without diabetic ketoacidosis (DKA) at T2D onset
- DKAn = 56
- Outcome
- Prevalence and characteristics of A-β+ KPD (RADIANT criteria) among children with DKA at T2D onset
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Met RADIANT A-β+ KPD criteria among children with DKA
DKA
45%
25 of 56
Observational data: associations, not effects.
Further findings
DKA at diagnosis, lacking islet autoantibodies
- Presented with DKA at diagnosis and lacked islet autoantibodies
- 56 (7.8%)
Clinical characteristics, DKA vs no DKA · diagnosis
- Children with DKA were older and had lower C-peptide and higher glucose than those without DKA
Characteristics of A-β+ ketosis-prone diabetes (KPD) children
- Male
- 64%
- African American or Hispanic
- 96%
- C-peptide at presentation with DKA (ng/mL)
- 1.3 ± 0.7
- HbA1c at follow-up (median 1.3 years postdiagnosis)
- 6.6% ± 1.9%
Original publication
High Prevalence of A−β+ Ketosis-Prone Diabetes in Children with Type 2 Diabetes and Diabetic Ketoacidosis at Diagnosis: Evidence from the Rare and Atypical Diabetes Network (RADIANT). Pediatr Diabetes. Published 4 March 2024. doi:10.
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