Type 2 & other diabetes

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes

Diabetes CarePublished Diagnostic accuracy study

Authors' conclusion

PEPPER streamlines EMR review, significantly reducing manual effort without sacrificing accuracy.

Study context

Population
Youth with T2D; identification of those with diabetic ketoacidosis (DKA) within 6 months of diagnosis, as first step to identify A-β+ ketosis-prone diabetes (KPD)
Participants
1,660 electronic charts
Comparison
PEPPER automated electronic medical record (EMR) search vs manual review
Outcome
Chart review time per chart
Methodological detailsEMR search tool vs manual review
  • EMR search tool vs manual review

Performance

As reported in the abstract

Test or modelValueAccuracy
PEPPERmean 13.4 (SD 3.9) s100%
Manual reviewmean 26.6 (SD 9.4) s

Value

PEPPERmean 13.4 (SD 3.9) s
Manual reviewmean 26.6 (SD 9.4) s

Accuracy

PEPPER100%
Manual review— not stated in the abstract
  • PEPPER vs Manual review: P < 0.001

Further findings

Youth with T2D and DKA identified by PEPPER, and those meeting full A-β+ KPD criteria

Youth with T2D and DKA identified
110
Met full A-β+ KPD criteria
21

Original publication

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes. Diabetes Care. Published 26 June 2026. doi:10.2337/dc26-0464

Composed by AI from the published abstract and checked against it. How Briefs are made →

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