Amino Acids and Classification and Regression Tree (CART) Distinguish A−β+ Ketosis-Prone Diabetes From Type 1 and Type 2 Diabetes During Hyperglycemic Crises
Authors' conclusion
During DKA, KPD and T1D patients have similarly altered amino acid profiles that differentiate them from T2D patients. Elevated protein catabolic hormones drive altered amino acid metabolism in KPD, rather than insulin deficiency as with T1D. A combination of 6 analytes differentiates KPD from T1D and T2D during hyperglycemic crises.
Study context
- Population
- Adults with ketosis-prone diabetes (KPD), T1D and T2D during hyperglycemic crises with or without diabetic ketoacidosis (DKA), and healthy controls, at an urban hospital emergency center
- Exposure
- KPD vs T1D vs T2D vs healthy controls during hyperglycemic crises
- Outcome
- Serum amino acids, hormones and CART classification
Methodological detailssingle-centre, urban hospital emergency center
- Single-centre
- Urban hospital emergency center
Main finding
As reported in the abstract
- Concentrations of most amino acids similar in KPD and T1D and lower vs T2D
- P < .05
- C-peptide cutoff differentiating T1D from KPD during DKA
- 0.496 ng/mL
Observational data: associations, not effects.
Original publication
Amino Acids and CART Distinguish A−β+ Ketosis-Prone Diabetes From Type 1 and Type 2 Diabetes During Hyperglycemic Crises. J Clin Endocrinol Metab. Published 16 January 2025. doi:10.
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