The Association Between Serum Polychlorinated Biphenyls and Incident Cardiovascular Disease Among Type 2 Diabetes
Authors' conclusion
Serum PCB independently increased the risk of incident CVD among T2D cases, in which lower-chlorinated PCBs played a dominant role.
Study context
- Population
- Participants with T2D from the Dongfeng-Tongji cohort, 2008, followed up until December 31, 20181,180 developed cardiovascular disease (CVD)
- Participants
- 2,806 participants
- Exposure
- Serum PCB quartiles
- Outcome
- Incident CVD
- Follow-up
- Until December 31, 2018
Methodological detailsDongfeng-Tongji cohort, Cox proportional hazard regression, quantile g-computation
- Dongfeng-Tongji cohort
- Cox proportional hazard regression
- Quantile g-computation
Main finding
As reported in the abstract
Incident CVD by serum PCB quartile
HR, lower-chlorinated PCBs (PCB28 + PCB52 + PCB101) (95% CI)P value
Q3vs Q1
1.257(1.063–1.486)
Q4vs Q1
1.346(1.139–1.589)
P = 0.001for trend- Q4 vs Q1
- increase in risk, PCB28 25%
- Q4 vs Q1
- increase in risk, PCB52 30%
- Q4 vs Q1
- increase in risk, PCB101 28%
Observational data: associations, not effects.
Further findings
Mixed PCB exposure (quantile g-computation)
- Mixed exposure to polychlorinated biphenyls (PCBs) increased the risk of CVD; top 3 weights: PCB101, PCB52, PCB28
Original publication
The Association Between Serum Polychlorinated Biphenyls and Incident Cardiovascular Disease Among Type 2 Diabetes. J Clin Endocrinol Metab. Published 15 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →