Remnant Cholesterol Is an Independent Predictor of Type 2 Diabetes: A Nationwide Population-Based Cohort Study
An erratum to this article was published (Diabetes Care, 1 Oct 2023 ↗)
Authors' conclusion
These findings indicate that remnant-C profiles provide additional information in predicting future progression of T2D, independent of the conventional lipid parameters.
Study context
- Population
- Korean adults without diabetes who participated in the national health screening in 2009, followed up until 2019
- Participants
- 8,485,539 adults
- Exposure
- Remnant-C quartiles
- Outcome
- Incident T2D
- Follow-up
- Median 9.28 years
Methodological detailsnationwide, population-based, longitudinal
- Nationwide
- Population-based
- Longitudinal
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Q2vs Q1
1.25(1.24–1.27)
Q3vs Q1
1.51(1.50–1.53)
Q4vs Q1
1.95(1.93–1.97)
- Developed T2D (overall cohort)
- 584,649 (6.8%)
Observational data: associations, not effects.
Further findings
Incident T2D by subgroup
- Risk increase with high remnant cholesterol (remnant-C) more profound in those with fewer traditional T2D risks, such as women, and absence of impaired fasting glucose, hypertension and atherogenic dyslipidemia
- Increased risk with higher remnant-C quartiles greater in younger than older participants
Original publication
Remnant Cholesterol Is an Independent Predictor of Type 2 Diabetes: A Nationwide Population-Based Cohort Study. Diabetes Care. Published 5 December 2022. doi:10.
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