Remnant cholesterol is an independent risk factor for the incidence of chronic kidney disease in newly-diagnosed type 2 diabetes: A nationwide population-based study
Main finding · Incident CKDResult — go to the resultHazard ratio 1.234 95% CI 1.159–1.314Authors' conclusion
In newly-diagnosed type 2 diabetes patients, higher remnant-C is independently associated with CKD incidence, even when conventional lipid values are well-controlled.
Study context
- Population
- Patients with newly-diagnosed T2D, 2009–2014, Korean National Health Insurance Service data6,850 chronic kidney disease (CKD) cases
- Participants
- 212,836 patients
- Exposure
- Highest vs lowest tertile of baseline remnant cholesterol
- Outcome
- Incident CKD
- Follow-up
- Median 5.23 years
Methodological detailsnationwide population-based
- Nationwide population-based
Main finding
As reported in the abstract
Hazard ratio
1.234
95% CI 1.159–1.314
Highest tertilevs Lowest tertile
HR 1.234 (95% CI 1.159–1.314)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Incident CKD, highest tertile, in patients within target range of conventional lipidsHighest tertilevs LowestLDL-C < 100 mg/dL | 1.165 (1.041–1.304) | |
| Incident CKD, highest tertile, in patients within target range of conventional lipidsHighest tertilevs LowestLDL-C < 70 mg/dL | 1.308 (1.063–1.609) | |
| Incident CKD, highest tertile, in patients within target range of conventional lipidsHighest tertilevs LowestHDL-C within target range | 1.243 (1.155–1.338) | |
| Incident CKD, highest tertile, in patients within target range of conventional lipidsHighest tertilevs LowestTG within target range | 1.168 (1.076–1.268) | |
| 0.512Hazard ratio (log scale) |
Incident CKD by hypertension or low-income status
- Association more prominent in patients with hypertension or low-income status
- P for interaction < 0.05
Original publication
Remnant cholesterol is an independent risk factor for the incidence of chronic kidney disease in newly-diagnosed type 2 diabetes: A nationwide population-based study. Diabetes Res Clin Pract. Published 26 March 2024. doi:10.
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