Association between remnant cholesterol and chronic kidney disease: Systematic review and meta‐analysis
Pooled result · CKDResult — go to the resultOdds ratio 1.46 95% CI 1.26–1.68Authors' conclusion
RC is directly associated with higher risk for CKD. Beyond traditional lipid markers, greater emphasis should be placed on RC levels in individuals with or at risk for CKD.
Study context
- Population
- Participants of studies on remnant cholesterol (RC) and chronic kidney disease (CKD); Medline, Cochrane Library and Scopus searched until 16 September 2024
- Participants
- 4,139,674 participants12 studies
- Comparison
- Highest vs lowest RC quantile
- Outcome
- Association between RC and CKD
Methodological detailsrandom-effects meta-analyses, double-independent study selection, data extraction and quality assessment
- Random-effects meta-analyses
- Double-independent study selection, data extraction and quality assessment
Pooled result
CKD
Odds ratio
1.46
95% CI 1.26–1.68
Highest RC quantilevs Lowest RC quantile
OR 1.46 (95% CI 1.26–1.68)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| CKD in T2D (sensitivity analysis)Sensitivity analysis confined to T2D | 1.46 (1.20–1.78) | |
| 0.512Odds ratio (log scale) |
eGFR per 1 mmol/L increase in RC
- MD in eGFR per 1 mmol/L RC increase (95% CI −2.67, −0.19); significant inverse association
- −1.43 mL/min/1.73 m²
Progression to end-stage renal disease in T2D-related CKD, per 1 SD increase in RC
- HR per 1 SD RC increase (95% CI 1.04-1.47); 24% increased risk
- 1.24
Original publication
Association between remnant cholesterol and chronic kidney disease: Systematic review and meta‐analysis. Diabetes Obes Metab. Published 14 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →