Long-term lifestyle intervention can reduce the development of type 2 diabetes mellitus in subjects with prediabetes: A systematic review and meta-analysis
Pooled result · T2D riskResult — go to the resultRelative risk 0.78 95% CI 0.72–0.85Authors' conclusion
ILI can prevent T2D in subjects with PD. Healthcare teams should aim for structured ILI to maintain long-term lifestyle improvements.
Study context
- Population
- Adults with prediabetes; 46.7 % female, 53.3 ± 8.7 years, BMI 26.7 ± 5.4 Kg/m²
- Participants
- 8,563 adults15 studies
- Comparison
- Intensive lifestyle intervention vs general advice
- Outcome
- Incidence of T2D
Methodological detailsrandom effects models, Cochrane Risk of Bias (RoB) 2.0, GRADE, Most studies had high risk of bias or raised some concerns
- Random effects models
- Cochrane RoB 2.0
- GRADE
- Most studies had high risk of bias or raised some concerns
Pooled result
T2D risk
Relative risk
0.78
95% CI 0.72–0.85
ILIvs General advice
RR 0.78 (95% CI 0.72–0.85)
As reported in the abstract
- Intensive lifestyle intervention (ILI) reduced T2D risk vs general advice
- 22 %
Further pooled results
Sensitivity analysis
- Studies with mostly female populations and those using WHO 1985 criteria for T2D had lower risk of the disease
- The longer the follow-up, the lower the protection
Original publication
Long-term lifestyle intervention can reduce the development of type 2 diabetes mellitus in subjects with prediabetes: A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 26 March 2024. doi:10.
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