Weight Loss Differentially Impacts Sex Hormones in Women and Men With Type 2 Diabetes: Look AHEAD Sex Hormone Study
Authors' conclusion
Weight loss in T2D resulted in sex hormone changes, which varied by sex and were mediated by changes in waist circumference. Changes in sex hormones due to weight loss in T2D should be considered in the context of an individual's health risks, including cardiovascular conditions, bone health, menopausal symptoms, and cognitive function.
Study context
- Population
- Postmenopausal women and men with T2D and body mass index (BMI) ≥25 kg/m²; baseline mean age 60 years
- Comparison
- Intensive lifestyle intervention vs comparison
- Primary endpoint
- Changes in total testosterone (T), estradiol (E2), SHBG and calculated bioavailable T (bioT)
Primary result
As reported in the abstract
Sex hormone changes with ILI · year 1
- Women: E2 decreased with intensive lifestyle intervention (ILI)
- 15%
- Women: Bioavailable T (bioT) decreased with ILI
- 13%
- Women: SHBG increased with ILI
- 21%
- Men: T increased with ILI
- 14%
- Men: SHBG increased with ILI
- 18%
Further findings
Durability, sex differences and mediation · 4 years
- Effect attenuated over 4 years
- Statistically significant sex differences in treatment effect
- Change in waist circumference due to ILI at year 1 was a significant mediator of sex hormone changes
Original publication
Weight Loss Differentially Impacts Sex Hormones in Women and Men With Type 2 Diabetes: Look AHEAD Sex Hormone Study. J Clin Endocrinol Metab. Published 2 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →