Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study
Authors' conclusion
ILI-associated changes in estradiol and total testosterone resulted in whole-body and hip bone loss, providing insights in the potential role of sex hormones in bone loss accompanying weight loss in older adults with T2D who are at a higher risk of bone fractures.
Study context
- Population
- Postmenopausal women and older men with overweight/obesity and T2D, Look AHEAD Sex Hormone Ancillary Study
- Comparison
- Intensive Lifestyle Intervention (ILI) vs Diabetes Support and Education (DSE)
- Primary endpoint
- Sex hormone (E2, total testosterone, bioavailable testosterone, sex hormone binding globulin (SHBG) at year 1) mediation of ILI effects on hip, femoral neck and whole-body bone mineral density (BMD), by sex
- Follow-up
- 4 years
Methodological detailsancillary study, structural equation models, mediation analysis
- Ancillary study
- Structural equation models
- Mediation analysis
Primary result
As reported in the abstract
BMD change mediated by sex hormones
ILI vs DSEEstimate (95% CI)
Women
Whole-body BMD decline mediated by 14% E2 decrease (women) −1.15 mg/cm²(−2.54 to −0.21)
Men
Hip BMD decline mediated by 11% total testosterone increase (men) −1.18 mg/cm²(−2.68 to −0.13)
- ILI-associated decrease in E2 from baseline to year 1 (women)
- 14%
- ILI-associated increase in total testosterone (men)
- 11%
Original publication
Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study. J Clin Endocrinol Metab. Published 17 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →