Long‐term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes
Authors' conclusion
ILI-related changes in weight, fat, and lean mass were detectable 12 to 16 years after randomization in men but, for unknown reasons, not in women. There was no evidence that the intervention led to a disproportionate loss of lean mass by the end of the study.
Study context
- Population
- Adults with T2D in the Look AHEAD DXA substudy who completed the final visit; mean (SD) age 57.2 (6.4) years and BMI 34.9 (5.1) kg/m² at randomizationcompleted final visit
- Comparison
- Intensive lifestyle intervention vs diabetes support and education
- Primary endpoint
- Weight and body composition (total and regional fat and lean masses by DXA)
- Follow-up
- 12 to 16 years after randomization
Methodological detailsDXA substudy, linear mixed-effects regression adjusted for group, clinic, sex, age, race/ethnicity and baseline body composition
- DXA substudy
- Linear mixed-effects regression adjusted for group, clinic, sex, age, race/ethnicity and baseline body composition
Primary result
As reported in the abstract
Weight and body composition
Men: weight and most body compartments reduced with intensive lifestyle intervention (ILI) vs diabetes support and education (DSE)
2% to 8%
Men: BMI reduced with ILI vs DSE
4%
Further findings
Percent lean mass · 16 years after randomization
- ILI-induced loss of lean tissue did not show a lower percent lean mass vs DSE
Original publication
Long‐term sustained effects of the Look AHEAD lifestyle intervention on body composition among adults with type 2 diabetes. Obesity (Silver Spring). Published 13 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →