Polygenic Risk Score Modifies the Association of HbA1c With Hearing Loss in Middle-Aged and Older Chinese Individuals: The Dongfeng-Tongji Cohort
Authors' conclusion
PRS modifies the association of HbA1c with HL prevalence among middle-aged and older Chinese individuals.
Study context
- Population
- Middle-aged and older Chinese individuals aged 64.9 years, Dongfeng-Tongji cohort
- Participants
- 13,275 participants
- Exposure
- Glycemic traits and polygenic risk score (PRS) for hearing loss
- Outcome
- Hearing loss (pure tone average >25 dB in the better ear) and its severity
Main finding
As reported in the abstract
Associations of glycemic traits (elevated FPG, HbA1c, T2D) with HL and its severity
- Elevated fasting plasma glucose (FPG), HbA1c and T2D positively associated with higher hearing loss (HL) risks and severity; Odds ratios (ORs) ranged from 1.04 (95% CI 1.00, 1.08) to 1.25 (95% CI 1.06, 1.46)
- Significant interaction between HbA1c and PRS on overall HL and its severity (P for multiplicative interaction <0.05); HbA1c effects on HL significant only with high PRS
- T2D with high PRS vs normoglycemia with low PRS: OR up to 2.00 (overall HL) and 2.40 (moderate to severe HL) (P for additive interaction <0.05)
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Overall HL: T2D with high PRS vs normoglycemia with low PRSUp to | 2.00 | P for additive interaction <0.05 |
| Moderate to severe HL: T2D with high PRS vs normoglycemia with low PRSUp to | 2.40 | P for additive interaction <0.05 |
Original publication
Polygenic Risk Score Modifies the Association of HbA1c With Hearing Loss in Middle-Aged and Older Chinese Individuals: The Dongfeng-Tongji Cohort. Diabetes Care. Published 10 May 2024. doi:10.
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