Prognostic stratification of cardiovascular risk and cardiac remodeling in prediabetes: a multimodal analysis comparing ADA and WHO/IEC diagnostic criteria
Authors' conclusion
These findings highlight the differential prognostic utility of ADA and WHO/IEC criteria for cardiovascular risk stratification in prediabetes.
Study context
- Population
- Participants without baseline cardiovascular disease (CVD), with complete glycemic and relevant assessment data
- Participants
- 278,697 participants
- Exposure
- Prediabetes vs normoglycemia
- Outcome
- Incident CVD
- Follow-up
- 13.5 years
Methodological detailsmultivariable-adjusted, exploratory CMR substudy
- Multivariable-adjusted
- Exploratory CMR substudy
Main finding
As reported in the abstract
Each group vs normoglycemiaHazard ratio (95% CI)
Prediabetes (ADA)
1.14(1.12–1.16)
Prediabetes (WHO/IEC)
1.23(1.19–1.27)
Observational data: associations, not effects.
Further findings
Mortality
- Stronger mortality associations in WHO/IEC-defined prediabetes
Mendelian randomization (MR): genetically predicted prediabetes and outcomes
- CVD, OR
- 1.01 (1.01-1.02) (95% CI)
- Coronary heart disease, OR
- 1.09 (1.02-1.17) (95% CI)
- MI, OR
- 1.12 (1.06-1.19) (95% CI)
- Stroke, OR
- 1.06 (1.02-1.10) (95% CI)
- Primary hypertension, OR
- 1.01 (1.01-1.02) (95% CI)
Cardiac remodeling (CMR substudy, n = 2512)
- Early concentric LV remodeling suggested, particularly under WHO/IEC criteria
- Exploratory
Genetic susceptibility strata
- Risks consistently observed across genetic susceptibility strata; no significant interaction
Original publication
Prognostic stratification of cardiovascular risk and cardiac remodeling in prediabetes: a multimodal analysis comparing ADA and WHO/IEC diagnostic criteria. Cardiovasc Diabetol. Published 3 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →