Association of weekday sleep duration and estimated glucose disposal rate: the role of weekend catch-up sleep
Authors' conclusion
This study revealed a significant inverted U-shaped relationship between weekday sleep duration and eGDR, identifying an optimal duration of approximately 7.32 hours, and that WCS is beneficial only in moderation and specifically for those with weekday sleep debt, whereas it may be detrimental for those who already sleep sufficiently. These findings underscore the importance of personalized sleep recommendations.
Study context
- Population
- US adults in the National Health and Nutrition Examination Survey (2009–2023)
- Participants
- 23,475 adults
- Exposure
- Weekday sleep duration and WCS vs no WCS
- Outcome
- eGDR (marker of insulin resistance (IR)) by weekday sleep duration
Methodological detailsNHANES 2009-2023
- NHANES 2009-2023
Main finding
As reported in the abstract
Inverted U-shaped relationship (restricted cubic splines (RCS)), inflection point
7.32 hours
Below threshold, per increase in sleep: β (95% CI 0.224 to 0.322), p<0.001
0.273
Above threshold: β (95% CI −0.272 to −0.171), p<0.001
−0.222
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| WCS and eGDR in those with <7.32 hours weekday sleep1-2 hours WCS vs No WCS · increased eGDR with 1-2 hours WCS · multivariable regression | 0.296 (0.107–0.484) | P = 0.002 |
Moderation of weekday sleep–estimated glucose disposal rate (eGDR) relationship by >2 hours WCS
- >2 hours WCS negatively moderated the relationship: β (95% CI −0.970 to −0.167), p=0.005
- −0.568
Original publication
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