Differences in Continuous Glucose Monitoring Metrics Between Prediabetes and Normoglycemia: A Systematic Review and Meta-Analysis
Pooled result · MAGEResult — go to the resultMD 9.41 mg/dL 95% CI 4.31–15.31Authors' conclusion
These results provide the first quantitative evidence that CGM can discriminate between prediabetes and normoglycemia, supporting its potential as a complementary tool for refined metabolic risk assessment. Further prospective studies are needed to determine its predictive value for progression to T2DM.
Study context
- Population
- Individuals with prediabetes vs normoglycemia; PubMed, EMBASE and CENTRAL searched from inception to September 3, 202510 studies in quantitative synthesis
- Participants
- 1,657 individuals
- Comparison
- Prediabetes vs normoglycemia
- Outcome
- Mean amplitude of glycemic excursions (MAGE)
Methodological details16 studies met inclusion criteria; 10 in quantitative synthesis
- 16 studies met inclusion criteria; 10 in quantitative synthesis
Pooled result
MAGE
MD
9.41 mg/dL
95% CI 4.31–15.31
Prediabetesvs Normoglycemia
MD 9.41 mg/dL (95% CI 4.31–15.31)
As reported in the abstract
Further pooled results
| Outcome | MD (%) (95% CI) | |
|---|---|---|
| TAR% | 5.68 (1.04–10.32) | |
| −5051015Difference, % (linear scale) |
| Outcome | MD (mg/dL) (CI) | |
|---|---|---|
| 24-hour mean glucose | 7.91 (6.27–9.55) | |
| −50510Difference, mg/dL (linear scale) |
Original publication
Differences in Continuous Glucose Monitoring Metrics Between Prediabetes and Normoglycemia: A Systematic Review and Meta-Analysis. J Diabetes Sci Technol. Published 3 March 2026. doi:10.
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