Associations of accelerometer-measured weekend sleep catch-up and loss with risk of type 2 diabetes: a prospective cohort study
Authors' conclusion
Weekend sleep catch-up could be a potential strategy against T2D among individuals with sleep deprivation during weekdays.
Study context
- Population
- Adults aged 43–79 years from the UK Biobank with wrist-worn accelerometer data
- Participants
- 80,414 adults
- Exposure
- Weekend sleep catch-up and loss vs no catch-up/loss
- Outcome
- Incident T2D (linked medical records, death registers and self-reported diagnosis)
- Follow-up
- Median (IQR) 7.3 years (6.8-7.8 years)
Methodological detailsaccelerometer-measured sleep, UK Biobank
- Accelerometer-measured sleep
- UK Biobank
Main finding
As reported in the abstract
T2D risk · median follow-up 7.3 years
Short weekday sleep: weekend sleep catch-up >1.5 h associated with lower T2D risk, HR
0.64 (0.45-0.92) (95 % CI)
Normal weekday sleep: weekend sleep loss associated with higher T2D risk, HR
1.33 (1.01-1.76) (95 % CI)
Incident T2D cases
1,465
Cumulative incidence of T2D
1.8 %
Observational data: associations, not effects.
Further findings
- Weekend sleep catch-up and loss showed distinct metabolic biomarker and metabolomic responses
- Tyrosine, leucine, creatinine and some lipid metabolites may link weekend sleep catch-up and loss to T2D
Original publication
Associations of accelerometer-measured weekend sleep catch-up and loss with risk of type 2 diabetes: a prospective cohort study. Diabetes Res Clin Pract. Published 22 August 2025. doi:10.
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